Finnish Sample Collections

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Studies

Cohort tables, explanations and references.

Cohort

PI

URL

ATBC study

Jarmo Virtamo / KTL

www.ktl.fi/portal/suomi/osastot/epidemiologia_ja_terveyden_edistaminen/yksikot/syovanehkaisytutkimusyksikko

/syovanehkaisytutkimus_(setti)/

Finnish Twin Cohort

Jaakko Kaprio KTL and HU

www.twinstudy.helsinki.fi

Finrisk

Erkki Vartiainen / KTL

http://www.ktl.fi/portal/english/osiot/research,_people___programs/epidemiology_and_health_promotion/units/

chronic_disease_epidemiology_unit/the_national_finrisk_study/

Helsinki Sudden Death Study

Pekka Karhunen / TaY

www.uta.fi/laitokset/laaket/bio/research/forensicmedicine.html

Health 2000

Arpo Aromaa / KTL

http://www.ktl.fi/terveys2000/

KTL Psychatric collections

Jouko Lönnqvist / KTL

http://www.ktl.fi/portal/suomi/osastot/mielenterveys_ja_alkoholitutkimus/tutkimus/mielenterveys/epidemiologia_ja_genetiikka/

Northern Finland Birth Cohort

Marjo-Riitta Järvelin / OU

http://cc.oulu.fi/~kttylwww/psko1966.html

 

KTL: National Public Health Institute, Finland; HU: University of Helsinki; Tay: University of Tampere; OU: University of Oulu

 

 


 Sample collections of the cohorts

 

Cohort

Total cohort (n)

DNA samples (n)(%)

Average DNA yield**

Serum (n)

Other samples***

 

ATBC study

29 000

2122 (7.3)*

144

29 000

n

 

Finnish Twin Cohort

42 000

12040 (28.7)

324

1 000

sess

 

Finrisk 1992-2002

23 297

20850 (89.5%)

278

From all

sess

 

    92

6051

5784

154

6025

sess

 

    97

8447

8791

285

7150?

sess

 

    02

8799

8758

-

8788

sess

 

Helsinki Sudden Death Study

1400

1400 (100)

-

700

ft, pt(ss), u(ss)

 

Health 2000

7419 (8000)

6824 (91.9)

401

8000

sess

 

KTL Psychatric collections

9728

2142 (22.0)

240

-

c(ss)

 

Northern Finland Birth Cohort 1966 & 1985-86

~12 000

11652

300

From all

p, sess

 

Helsinki Sudden Death Study

700

0

0

0

pt, c(ss), ft(ss)

 

Autoklinikat

57 000

0

0

57 000

p

 

Mini-Suomi

7217

0

0

7217

p, u

 

 

Total 212 358 excluding pathological collections
ss=subsample
sess =several subsamples
*extraction unfinished, samples from all
**amount still left
*** Plasma= p; frozen tissue = ft; tissue in paraffin =pt; urine= u; cells= c; nail clippings =n;


 Phenotype and registry data.

 

Cohort

Average follow-up yrs*

Clinical examination at baseline

Questionnaire topics

Interview topics

Laboratory examinations

Key publication describing study setting

ATBC study

12 (re+rg)**

doctor

Cardiovascular risk factors

Life style, risk factors

All: Cholesterol, HDL, α-tokopherol, β-carotene, pepsinogen-1

Marantz et al. 1994

Finnish Twin Cohort

20-28 (re+rg)

nurse/doctor (ss)

Disease-oriented

Disease-+several life style related

Several but only in subsamples: GWA (n=152), lipids, inflammation, genotyping (genome-wide scan from app. 1000 individuals)

Kaprio et al. 2002 (a+b)

Finrisk

30-2 yr (rg)

nurse

Life style, risk factors

Life style, risk factors

All: cholesterol, HDL, triglyserides (4hr fasting sample). Subsamples (GWA (n=2500), inflammation, thrombosis, OGT)

Vartiainen E et al 2002 + web

Forensic collections

no

autopsy

-

Life style, (subset) ††

Candidate genes in HSDS

Ilveskoski et al 1999

Health 2000

2 (rg)

Doctor, dentist

Health related

Health related

GWA (n=2200), ApoE2/3/4 genotypes, candidate gene analyses, lipids, uric acid, insulin, glucose (ss)

Web (Table Y)

KTL Psychatric collections

10 (rg)

Doctor+nurse

Addictions, somatic diseases

Psychiatric interview (n=1200)

GSD, some candidate genes, app. 1000 individuals

Hovatta 1998

Northern Finland Birth Cohorts

36+16(re+rg)

nurse

Disease-oriented

 

GWA (n=4988), insulin, Hb, glucose, hs_CRP, IgG, IgA, candidate gene genotyping (ss)

Heikura et al 2003

Helsinki Sudden Death Study

no

Autopsy/histological diagnosis

n/a

n/a

Histological diagnosis, clinical data

-

Autoklinikka

36-30 (rg)

Nurse, doctor ss

Life style, risk factors

Life style, risk factors

Hb, Hkr, EKG (ss)

Aromaa1981

Mini-Suomi

22 (rg)

Doctor, dentist

Life style, risk factors

Life style, risk factors

EKG, spirometry, Hkr, cholesterol, HDL, triglyserides, GGT, fs-glucose, kreatinine, sess (lipidfractions, Na, K…)

Aromaa et al 1989

 

* All cohorts with registry follow-up data use death registry and hospital discharge registry as their primary source of follow-up data
** rg=registry follow-up; re=re-call of the participants
† all listed questionnaire studies record basic clinical characteristics, such as height and weight
†† interview of a living associate (relative) for a subsample
HSDS=Helsinki Sudden Death Study
GSD=Genome-wide scan data (microsatellites)
GWA=Genome-wide association data
Ss= subsample
sess =several subsamples

References
Aromaa A. Kohonnut verenpaine ja sen kansanterveydellinen merkitys Suomessa. (English summary)  KELA AL: 17. Helsinki 1981
Aromaa A, Heliövaara M, Impivaara O, Knekt P, Maatela J, Joukamaa M, Klaukka T, Lehtinen V, Melkas T, Mälkiä E, Nyman K, Paunio I, Reunanen A, Sievers K, Kalimo E, Kallio V. Terveys, tomintakyky ja hoidontarve Suomessa. Mini-Suomi terveystutkimuksen perustulokset. (English summary) KELA AL: 32. Helsinki and Turku 1989.
Heikura U, Taanila A, Olsen P, Hartikainen AL, von Wendt L, Jarvelin MR. Temporal changes in incidence and prevalence of intellectual disability between two birth cohorts in Northern Finland. Am J Ment Retard. 2003 Jan;108(1):19-31.
Hovatta I. "Molecular genetics of familial schizophrenia and PLO-SL". PhD. Thesis University of Helsinki, 1998.
Ilveskoski E, Perola M, Lehtimaki T, Laippala P, Savolainen V, Pajarinen J, Penttila A, Lalu KH, Mannikko A, Liesto KK, Koivula T, Karhunen PJ. Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men: an autopsy study.Circulation. 1999 Aug 10;100(6):608-13.
Kaprio J, Pulkkinen L, Rose RJ. Genetic and environmental factors in health-related behaviors: studies on Finnish twins and twin families.
Twin Res. 2002 Oct;5(5):366-71. (a)
Kaprio J, Koskenvuo M. Genetic and environmental factors in complex diseases: the older Finnish Twin Cohort.
Twin Res. 2002 Oct;5(5):358-65. (b)
The ATBC Cancer Prevention Study
Group. The Alpha-Tocopherol, Beta-Carotene Lung Cancer Prevention Study:
design, methods, participant characteristics, and compliance. Ann
Epidemiol 1994;4:1-10.
Vartiainen E, Laatikainen T, Tapanainen H, Salomaa V, Jousilahti P, Sundvall J, Salminen I, Männistö S, Valsta L. Suomalaisten sydän- ja verisuonitautien riskitekijät FINRISKI-tutkimuksessa 1982-2002. Suom Lääkäril 2003;41:4099-4106