Finnish Sample Collections

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THL Psychiatric Family Collections

The THL Psychiatric Family collections include families ascertained for bipolar spectrum disorders (BPD), schizophrenia and schizoaffective disorder. The BPD families include individuals born between 1940 and 1969 and hospitalized with a diagnosis of BPD and their family members (N=1329). For schizophrenia, in 1994–2008, the study’s participants consisted of about 3500 people from families where a member of the family has schizophrenia.

http://www.thl.fi/en_US/web/en/project?id=23716

THL – The National Institute for Health and Welfare
Principal Investigators:
Schizophrenia – Jouko Lönnqvist, firstname.lastname (at) thl.fi 
Bipolar (clinical) – Timo Partonen, firstname.lastname (at) thl.fi
Bipolar (genetics) – Tiina Paunio, firstname.lastname (at) thl.fi

Contact persons:
Schizophrenia – Jaana Suvisaari, firstname.lastname (at) thl.fi
Bipolar (clinical) – Timo Partonen, firstname.lastname (at) thl.fi
Bipolar (genetics) – Tiina Paunio, firstname.lastname (at) thl.fi

Key references:

Bipolar spectrum disorder:
Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments. Palo OM, Antila M, Silander K, Hennah W, Kilpinen H, Soronen P, Tuulio-Henriksson A, Kieseppä T, Partonen T, Lönnqvist J, Peltonen L, Paunio T. Hum Mol Genet. 2007;16(20):2517-28

Schizophrenia:
Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families. Wedenoja J, Loukola A, Tuulio-Henriksson A, Paunio T, Ekelund J, Silander K, Varilo T, Heikkilä K, Suvisaari J, Partonen T, Lönnqvist J, Peltonen L. Mol Psychiatry. 2008 Jul;13(7):673-84.

Hovatta I, Varilo T, Suvisaari J, Terwilliger JD, Ollikainen V, Arajärvi R, Juvonen H, Kokko-Sahin ML, Väisänen L, Mannila H, Lönnqvist J, Peltonen L. A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am J Hum Genet. 1999 Oct;65(4):1114-24