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GEHA (Genetics of Healthy Aging)

The integrated European project GEHA (Genetics of Healthy Ageing) aims at identifying genes involved in healthy ageing and longevity. The study sample includes 2535 families comprising 5319 nonagenarian (aged 90 years or more) siblings and 2548 younger control persons aged 50–75 years. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies). With recent mortality follow-up information, the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. The GEHA project represents a unique source in the search for genes related to healthy ageing and longevity. The study sample includes 450 old siblings and 176 young controls from Finland.

Key reference:
Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project. Skytthe A, Valensin S, Jeune B, Cevenini E, Balard F, Beekman M, Bezrukov V, Blanche H, Bolund L, Broczek K, Carru C, Christensen K, Christiansen L, Collerton JC, Cotichini R, de Craen AJ, Dato S, Davies K, De Benedictis G, Deiana L, Flachsbart F, Gampe J, Gilbault C, Gonos ES, Haimes E, Hervonen A, Hurme MA, Janiszewska D, Jylhä M, Kirkwood TB, Kristensen P, Laiho P, Leon A, Marchisio A, Masciulli R, Nebel A, Passarino G, Pelicci G, Peltonen L, Perola M, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Scurti M, Sevini F, Sikora E, Skouteri A, Slagboom PE, Spazzafumo L, Stazi MA, Toccaceli V, Toussaint O, Törnwall O, Vaupel JW, Voutetakis K, Franceschi C; GEHA consortium. Exp Gerontol. 2011 Nov;46(11):934-45